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DNA Specimen Provenance Assignment
DNA Specimen Provenance Assignment (DSPA) is a molecular diagnostic test used to definitively assign biopsy specimen identity during the diagnostic testing cycle for cancer and other histopathological conditions. The term first appeared in the 2011 scientific paper, “The Changing Spectrum of DNA-Based Specimen Provenance Testing in Surgical Pathology,” published in the ''American Journal of Clinical Pathology'', which built upon concepts described in an earlier paper published in the ''Journal of Urology''.
== Testing description ==
A panel of 16 microsatellite short tandem repeat (STR) markers that recognizes highly variable loci of human DNA is used in a PCR-based assay and analyzed by capillary gel electrophoresis. The 16 STR loci range from approximately 75 to 400 base pairs in length, and are highly polymorphic in the human population. The collective data from this panel provides a genetic profile, or ‘DNA fingerprint,’ representing the individual. To complete the diagnostic testing cycle for cancer, the genetic profile from the malignant specimen(s) is compared with the profile derived from the patient’s DNA reference sample, which is taken via cheek swab at the time of the biopsy procedure.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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